Prednisone, a corticosteroid, can worsen altitude sickness symptoms. This is because it suppresses the body’s natural inflammatory response, which plays a role in acclimatization to high altitude. Be aware of intensified symptoms and seek immediate medical attention if they occur.
Recognizing Worsened Symptoms
- Headache: Prednisone can intensify headaches, making them more severe and persistent than usual altitude sickness headaches. Severe or unrelenting headache should be considered a warning sign. Nausea and Vomiting: While common in altitude sickness, Prednisone may increase the frequency and intensity of nausea and vomiting, leading to dehydration. Fatigue and Weakness: Prednisone can cause increased fatigue. At altitude, this effect is amplified, potentially leading to significant weakness and impaired physical function. Shortness of Breath: Existing shortness of breath related to altitude sickness can be significantly worsened by Prednisone’s effects on lung function and oxygen utilization. Swelling: Prednisone can cause fluid retention, potentially exacerbating pulmonary or cerebral edema (fluid buildup in the lungs or brain), serious complications of altitude sickness.
What to Do
Descent: Immediate descent to a lower altitude is the most effective treatment for altitude sickness. This is even more crucial when taking Prednisone. Hydration: Drink plenty of fluids to counteract dehydration, a common consequence of both altitude sickness and Prednisone’s side effects. Medical Attention: Seek medical evaluation without delay if you experience severe symptoms, such as severe headache, altered mental status, or difficulty breathing. This is particularly important if you are on Prednisone. Medication Review: Discuss your Prednisone use with your doctor before traveling to high altitudes. They may adjust your dosage or recommend alternative strategies to manage your condition.
Remember, the combination of Prednisone and altitude can create a dangerous situation. Early recognition and prompt action are crucial for preventing serious complications.


