Sildenafil treatment for persistent pulmonary hypertension of the newborn (PPHN) typically begins with an initial dose of 1-2 mg/kg given intravenously (IV). This dose is repeated every 6-8 hours as needed.
Monitoring and Dose Adjustment
Close monitoring of the infant’s oxygen saturation, blood pressure, and clinical status is crucial. Adjustments to the sildenafil dosage are frequently made based on the infant’s response. If there’s insufficient improvement, the dosage may be increased gradually to a maximum of 10 mg/kg per dose, but always under strict medical supervision.
Oral Sildenafil
Once the infant is stable and able to tolerate oral medication, a transition to oral sildenafil may occur. The oral dose is generally equivalent to the effective intravenous dose. However, the exact oral dosage and schedule must be tailored individually to each infant.
Dosage Table (Illustrative)
| 2 | 2-4 | 20 |
| 3 | 3-6 | 30 |
| 4 | 4-8 | 40 |
Note: This table provides illustrative examples only. Dosage should always be determined by a physician based on the individual infant’s needs and response to treatment. This information is not a substitute for professional medical advice. Always consult with a healthcare provider for any questions regarding the treatment of PPHN.
Adverse Effects
Common side effects include hypotension, flushing, and mild gastrointestinal issues. Rarely, more severe side effects may appear. Close monitoring for these is necessary.
