Viagra’s primary mechanism involves specific vasodilation within the penis. This targeted dilation affects the arteries supplying the corpora cavernosa, the spongy erectile tissue within the penis.
Nitric oxide (NO) plays a central role. Sexual stimulation triggers NO release, relaxing smooth muscles in penile arteries. This relaxation increases blood flow into the corpora cavernosa, causing the penis to become erect.
Viagra, or sildenafil, inhibits the enzyme phosphodiesterase-5 (PDE5). PDE5 normally breaks down cGMP, a molecule that facilitates NO’s vasodilatory effect. By inhibiting PDE5, Viagra prolongs cGMP’s action, sustaining vasodilation and facilitating erection.
This targeted vasodilation is crucial. It’s not a generalized widening of blood vessels throughout the body. The localized effect on penile arteries is what enables its function in erectile dysfunction.
Factors influencing this specific vasodilation include nerve function, hormonal levels, and the overall health of the circulatory system. Maintaining cardiovascular health supports optimal erectile function.
Proper diagnosis by a healthcare professional is important to determine the underlying cause of erectile dysfunction and to ensure Viagra is the appropriate treatment.
