Sildenafil primarily inhibits phosphodiesterase-5 (PDE5), an enzyme that breaks down cyclic guanosine monophosphate (cGMP). Elevated cGMP levels relax vascular smooth muscle, leading to vasodilation. This mechanism is crucial in treating pulmonary hypertension (PH).
Improved Blood Flow in Pulmonary Arteries
In PH patients, the pulmonary arteries constrict, increasing blood pressure. Sildenafil’s vasodilatory effect targets these arteries, improving blood flow and reducing pressure. Studies show significant improvements in exercise capacity and quality of life for many patients.
Dosage and Considerations
The appropriate dosage depends on individual patient characteristics and response. Close monitoring of blood pressure and potential side effects is necessary. Sildenafil’s use in PH requires careful medical supervision. Patients should discuss any potential drug interactions with their physicians.
Specific PH Types and Sildenafil
Sildenafil’s effectiveness varies depending on the underlying cause of PH. It’s particularly beneficial for patients with group 1 PH (pulmonary arterial hypertension). However, its role in other PH types requires careful evaluation and may not always be appropriate. Consult a specialist for accurate diagnosis and treatment plan.
