Both tadalafil and sildenafil can cause side effects, though they vary in frequency and severity. Common side effects for both include headache, flushing, nasal congestion, and indigestion. Sildenafil may more frequently cause visual disturbances, such as blurred vision or changes in color perception. Tadalafil may cause back pain and muscle aches more often than sildenafil. Always consult a doctor if you experience any unusual or persistent side effects.
These medications interact with other drugs; understanding these interactions is vital for safe use. Nitrates, used to treat angina, are a significant concern. Combining them with either tadalafil or sildenafil can cause a dangerous drop in blood pressure. Alpha-blockers, often prescribed for high blood pressure or enlarged prostate, can also interact, potentially leading to dizziness or fainting. Certain antifungals, such as ketoconazole and itraconazole, can increase the blood levels of both medications, potentially intensifying side effects.
Other medications that may interact include:
| Protease inhibitors (HIV medications) | Ritonavir, saquinavir | Increased blood levels of tadalafil and sildenafil |
| CYP3A4 inhibitors | Erythromycin, clarithromycin | Increased blood levels of tadalafil and sildenafil |
| CYP3A4 inducers | Rifampin, St. John’s Wort | Decreased blood levels of tadalafil and sildenafil |
This table is not exhaustive. Always provide your doctor with a complete list of all medications, supplements, and herbal remedies you are taking before starting tadalafil or sildenafil. This allows your doctor to assess potential interactions and adjust dosages or choose alternative treatments if necessary. Failing to disclose medications can have serious health consequences.
