Prednisone can increase muscle breakdown (catabolism) and alter energy expenditure. This happens because prednisone promotes protein breakdown, reducing muscle mass. Studies show that prolonged use often leads to significant muscle wasting, especially in higher doses.
Increased Metabolic Rate, but Not Always Beneficial
While prednisone might initially elevate your metabolic rate, this increase isn’t necessarily a positive effect. The increased metabolism is often a consequence of the body’s increased effort to compensate for the catabolic effects of the drug, not a sign of improved metabolic health. This increased energy expenditure can lead to fatigue and weakness, alongside muscle loss.
Practical Considerations & Management
To mitigate muscle loss, consider incorporating a high-protein diet rich in essential amino acids. Regular resistance exercise, tailored to your individual condition and prescribed by your physician, is crucial. Your doctor might recommend nutritional supplements, such as creatine or protein powder, to support muscle growth. Open communication with your healthcare provider about any observed changes in muscle mass or energy levels is paramount for effective management.
