Monitor your cat closely for any unusual changes after starting azithromycin. Common side effects include vomiting and diarrhea. Less frequently, you might observe loss of appetite or lethargy. Severe reactions are rare, but immediate veterinary attention is necessary if you see signs of allergic reaction like swelling, difficulty breathing, or hives.
Gastrointestinal Upsets
Azithromycin can upset the stomach. To minimize this, administer the medication with food. If vomiting or diarrhea persists, contact your veterinarian.
Drug Interactions
Azithromycin can interact with certain medications. This is especially important if your cat is already taking other drugs. Always inform your vet about all medications, supplements, and even over-the-counter remedies your cat is receiving before starting azithromycin. The following table provides examples of potential drug interactions; this list is not exhaustive. Always consult your veterinarian to assess risk.
| Digoxin | Increased risk of digoxin toxicity. | Close monitoring of digoxin levels. |
| Warfarin | Potential alteration of anticoagulant effects. | Regular blood tests to monitor clotting time. |
| Theophylline | Increased theophylline levels. | Theophylline dose adjustment may be necessary. |
Kidney and Liver Function
Azithromycin is primarily excreted by the liver and kidneys. Cats with pre-existing liver or kidney disease may need a dose adjustment or alternative treatment. Always provide your vet with a complete medical history.


