Combining Zoloft (sertraline) and Wellbutrin (bupropion) can increase the risk of seizures, particularly in individuals with a pre-existing seizure disorder or those prone to seizures. This risk is generally low, but you should inform your doctor immediately if you experience any neurological symptoms such as unusual muscle twitching, involuntary movements, or changes in consciousness.
Both medications can affect appetite and weight. You might experience weight loss or gain, which is something to monitor. Increased anxiety and insomnia are also possible side effects. Changes in mood, including increased agitation or irritability, should also be reported to your doctor.
Serotonin syndrome is a rare but serious complication. Symptoms include confusion, agitation, sweating, muscle rigidity, fever, and rapid heart rate. Seek immediate medical attention if you suspect this complication. The risk is higher when starting or increasing either medication.
Gastrointestinal issues such as nausea, vomiting, diarrhea, or constipation are common side effects of both medications, often resolving with time or with adjustments to dosage. Headaches are also prevalent.
Your doctor should carefully monitor you for these and other potential side effects. Open communication with your healthcare provider is paramount for managing the combination therapy safely and effectively. Report any concerning symptoms immediately.
