Always inform your doctor about all medications you take, including over-the-counter drugs, supplements, and herbal remedies, before starting metformin. This helps avoid potentially harmful drug interactions.
Medications Affecting Kidney Function
Metformin is primarily eliminated by the kidneys. Therefore, medications that impair kidney function, such as nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen, and some antibiotics, can increase the risk of metformin-related side effects, including lactic acidosis – a rare but serious complication. Your doctor may need to adjust your metformin dosage or recommend alternative pain relievers.
Medications Increasing Blood Sugar
Some medications can counteract metformin’s blood sugar-lowering effects. These include corticosteroids (like prednisone), diuretics (water pills), and certain antipsychotics. Your doctor might need to adjust your metformin dose or add another diabetes medication to maintain adequate blood sugar control.
Alcohol and Metformin
Consuming alcohol while taking metformin increases the risk of lactic acidosis. Limit alcohol intake, especially large amounts. Consult your doctor regarding safe alcohol consumption levels.
Contrast Media and Metformin
Before undergoing procedures requiring iodine-based contrast media (like X-rays or CT scans), you might need to temporarily stop taking metformin to reduce the risk of kidney damage and lactic acidosis. Your doctor will advise on the necessary precautions.
Other Potential Interactions
Metformin can interact with other drugs, affecting their absorption, metabolism, or excretion. This applies to specific medications such as certain antihypertensives and some cardiac drugs. Discuss all your medications with your doctor or pharmacist to assess potential interactions and avoid complications.
