While generally well-tolerated, diclofenac topical gel can interact with certain medications. Always inform your doctor or pharmacist of all medications you’re taking, including over-the-counter drugs and supplements, before starting diclofenac topical therapy.
Interactions with Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
Combining diclofenac topical with oral NSAIDs (like ibuprofen or naproxen) increases the risk of side effects, particularly gastrointestinal issues such as ulcers or bleeding. Careful monitoring is recommended.
Interactions with Anticoagulants and Antiplatelet Drugs
- Diclofenac, even topically applied, can slightly increase the risk of bleeding when used with anticoagulants (like warfarin) or antiplatelet drugs (like aspirin or clopidogrel). Your doctor may need to adjust your dosage or monitor you more closely. Increased bruising or unusual bleeding warrants immediate medical attention.
Other Potential Interactions
Lithium: Diclofenac topical may increase lithium levels in your blood. Regular monitoring of lithium levels is advisable. Methotrexate: Concurrent use with methotrexate may increase the risk of methotrexate toxicity. Close monitoring is recommended. ACE inhibitors and Angiotensin Receptor Blockers (ARBs): Some studies suggest potential interactions that may reduce the effectiveness of these blood pressure medications. Your blood pressure should be closely monitored.
Managing Interactions
Your doctor can help you manage potential interactions by adjusting dosages, recommending alternative medications, or closely monitoring your health. Open communication with your healthcare provider is crucial for safe and effective treatment.
Important Note:
This information is not exhaustive. Always consult your healthcare professional for personalized advice regarding potential drug interactions with diclofenac topical gel.
