Interactions with Other Medications and Substances

Losartan can interact with several medications. Simultaneous use with potassium-sparing diuretics (like spironolactone or amiloride) increases potassium levels, potentially leading to dangerous hyperkalemia. Monitor your potassium levels closely if you’re taking both.

Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen or naproxen, can reduce Losartan’s effectiveness in lowering blood pressure. Consult your doctor about alternative pain relievers.

Lithium levels may rise when taken with Losartan, increasing the risk of lithium toxicity. Regular blood tests are necessary to monitor lithium levels if you use both medications.

Alcohol consumption can worsen Losartan’s side effects, particularly dizziness and lightheadedness. Limit alcohol intake while taking this medication.

Certain medications used to treat depression (MAO inhibitors) may increase Losartan’s blood pressure-lowering effects. Your doctor may need to adjust your Losartan dosage if you use such medications.

Always inform your doctor or pharmacist about all medications, supplements, and herbal remedies you are taking before starting Losartan. This ensures safe and effective use and helps prevent potential interactions.