Check for a variety of reactions. Doxycycline can cause several types of skin rashes, from mild to severe. Common reactions include maculopapular rashes (flat, red spots), erythema multiforme (target-shaped lesions), and photosensitivity (increased sun sensitivity leading to sunburn). Less common but potentially serious reactions are Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), characterized by widespread blistering and skin peeling.
Recognizing Specific Symptoms
Maculopapular rashes often appear as small, reddish bumps spread across the body. They might be itchy. Erythema multiforme shows up as characteristic “target” or “iris” lesions with concentric rings of color. Photosensitivity reactions manifest as sunburn-like reactions, even with minimal sun exposure. SJS and TEN present with more severe symptoms, including widespread blistering, fever, and mucosal involvement (mouth, eyes, genitals).
Note the timing of the rash. Skin reactions usually develop within days to weeks of starting doxycycline. This temporal relationship is a key indicator. Document the onset and progression of the rash. Take pictures if possible. This visual record aids diagnosis.
Seek medical attention immediately if you experience severe symptoms like widespread blistering, fever, or mucosal involvement. These could indicate SJS or TEN, requiring urgent treatment.
