Telmisartan HCTZ 80/25 combines two medications to lower blood pressure: telmisartan and hydrochlorothiazide (HCTZ). Telmisartan blocks angiotensin II, a hormone that narrows blood vessels. This blocking action allows blood vessels to relax and widen, reducing blood pressure. Hydrochlorothiazide is a diuretic; it increases urine production, helping your body eliminate excess sodium and water. This reduction in fluid volume also lowers blood pressure.
Telmisartan’s Mechanism
Telmisartan specifically targets the angiotensin II type 1 receptor (AT1 receptor). By preventing angiotensin II from binding to this receptor, it prevents vasoconstriction (narrowing of blood vessels) and aldosterone release. Less aldosterone means less sodium and water retention, further contributing to lower blood pressure. This dual action makes telmisartan highly effective in managing hypertension.
Hydrochlorothiazide’s Role
Hydrochlorothiazide (HCTZ) acts on the kidneys, increasing the excretion of sodium and water. This diuretic effect reduces blood volume, which in turn lowers blood pressure. The combined effect of telmisartan and HCTZ creates a synergistic effect, resulting in a more significant blood pressure reduction than either drug alone would provide. The 80/25 ratio refers to the dosage of each component–80mg of telmisartan and 25mg of HCTZ.
