This combination medication treats type 2 diabetes by improving your body’s response to insulin and reducing sugar production. Glipizide helps your pancreas release more insulin, while metformin lowers glucose production in your liver and improves insulin sensitivity in your muscles.
Dosage is critical. The 5/500 designation means 5mg of glipizide and 500mg of metformin per tablet. Always follow your doctor’s instructions precisely regarding the number of tablets and frequency of administration. Never adjust your dosage without consulting your physician. Incorrect dosage can lead to serious health complications.
Potential side effects include nausea, vomiting, diarrhea, and stomach upset. These are more common with metformin. Less frequent, but more serious, effects include low blood sugar (hypoglycemia) and lactic acidosis (a rare but dangerous condition). Regular blood sugar monitoring is vital; learn the symptoms of hypoglycemia and know how to respond appropriately. Contact your doctor immediately if you experience severe side effects.
Before starting this medication, discuss your medical history, including kidney and liver function, with your doctor. They’ll assess the safety and suitability of this treatment for your individual needs. Regular check-ups are necessary to monitor treatment effectiveness and adjust dosage as required.


