Etodolac can interact with several medications. Always inform your doctor or pharmacist about all medications, supplements, and herbal remedies you’re taking before starting etodolac. This includes over-the-counter drugs.
Nonsteroidal anti-inflammatory drugs (NSAIDs): Combining etodolac with other NSAIDs increases the risk of stomach ulcers and bleeding. Avoid concurrent use unless specifically directed by your physician.
Warfarin and other anticoagulants: Etodolac may increase the risk of bleeding when taken with anticoagulants like warfarin. Close monitoring of your blood clotting time is needed. Your doctor may adjust your anticoagulant dosage.
Lithium: Etodolac might reduce the kidneys’ ability to excrete lithium, potentially leading to increased lithium levels in your blood. Regular lithium level checks are recommended during combined use.
Methotrexate: Concurrent use with methotrexate may increase the risk of methotrexate’s toxic effects. Your doctor needs to carefully monitor you.
Diuretics: Etodolac can reduce the effectiveness of some diuretics. Your doctor might adjust your diuretic dosage to maintain optimal blood pressure control.
ACE inhibitors and angiotensin II receptor blockers (ARBs): Using etodolac with ACE inhibitors or ARBs may decrease their effectiveness in controlling blood pressure. Close monitoring of your blood pressure is recommended.
Corticosteroids: Combining etodolac with corticosteroids increases the risk of gastrointestinal bleeding and ulcers. Careful monitoring is necessary.
This information is not exhaustive. Consult your doctor or pharmacist for a complete list of potential interactions and personalized advice.
