Avoid alcohol completely. Mirtazapine’s sedative effects are significantly amplified by alcohol, leading to excessive drowsiness and impaired coordination.
Be cautious with other sedatives. This includes medications like benzodiazepines (e. g., Xanax, Valium), opioid pain relievers, and antihistamines. Combining these can cause dangerous respiratory depression.
Certain medications can affect mirtazapine’s metabolism:
- Strong CYP3A4 inhibitors (e. g., ketoconazole, ritonavir): These can increase mirtazapine levels, potentially intensifying side effects. Strong CYP3A4 inducers (e. g., rifampin, St. John’s Wort): These can decrease mirtazapine levels, reducing its effectiveness.
Monitor blood pressure carefully if taking other medications that affect blood pressure. Mirtazapine can cause a slight increase in blood pressure in some individuals.
Inform your doctor about all medications, supplements, and herbal remedies you are taking. This includes over-the-counter drugs. This is crucial for preventing harmful interactions.
Grapefruit juice can interact with some medications metabolized by the liver, similar to mirtazapine, though the impact is debated. It’s best to avoid it to be safe.
Always consult your doctor or pharmacist before starting or stopping any medication while on mirtazapine. They can assess potential risks and adjust your treatment accordingly.
Never self-medicate. Follow your doctor’s instructions precisely. Report any unusual symptoms or side effects immediately.
