Calculating Equivalent Doses: A Step-by-Step Guide

Prednisone and Solu-Cortef (hydrocortisone) are both corticosteroids, but they have different potencies. To convert between them, you need to understand their relative strengths. Generally, 20 mg of prednisone is considered equivalent to 40 mg of hydrocortisone.

Prednisone to Solu-Cortef Conversion

Follow these steps for accurate conversion:

Determine the Prednisone Dose: Begin with the prednisone dosage you need to convert. For example, let’s say you’re working with a 10 mg prednisone dose. Apply the Conversion Ratio: Use the ratio of 1:2 to convert prednisone to hydrocortisone. This means for every 1 mg of prednisone, you need 2 mg of hydrocortisone. Calculate the Hydrocortisone Equivalent: Multiply the prednisone dose by 2. In our example: 10 mg prednisone x 2 = 20 mg hydrocortisone. Confirm the Dose: You’ve now calculated that 10 mg of prednisone is equivalent to 20 mg of hydrocortisone (Solu-Cortef).

Solu-Cortef to Prednisone Conversion

Converting Solu-Cortef back to prednisone is equally straightforward:

Determine the Solu-Cortef Dose: Start with the hydrocortisone dose. For instance, let’s use 40 mg of hydrocortisone. Apply the Conversion Ratio: Use the ratio of 2:1. This means for every 2 mg of hydrocortisone, you get 1 mg of prednisone. Calculate the Prednisone Equivalent: Divide the hydrocortisone dose by 2. In this example: 40 mg hydrocortisone / 2 = 20 mg prednisone. Confirm the Dose: You’ve calculated that 40 mg of hydrocortisone is equivalent to 20 mg of prednisone.

Important Note: Always consult your doctor or pharmacist before making any changes to your medication regimen. These calculations are for informational purposes only and should not replace professional medical advice.

    This information should not be used for self-treatment. Individual needs may vary. Dosage adjustments must be made under professional guidance.