Accutane, or isotretinoin, powerfully combats acne by targeting several key processes within the skin. It primarily reduces sebum production, the oily substance that clogs pores and fuels acne development. This occurs through a decrease in sebaceous gland size and activity.
Reducing Sebum Production
- Isotretinoin binds to retinoic acid receptors in sebaceous glands. This binding triggers a reduction in sebum secretion. The result is significantly less oil available to contribute to acne breakouts.
Beyond sebum control, Accutane also influences the way skin cells behave. It modifies the rate at which skin cells renew, preventing the formation of comedones (blocked pores), a foundational step in acne development.
Modifying Skin Cell Behavior
Isotretinoin decreases the rate of keratinocyte proliferation, reducing pore blockage. It alters the differentiation of these cells, making them less likely to clump and form microcomedones. This leads to fewer blocked pores and, consequently, fewer inflammatory lesions.
Finally, Accutane demonstrates anti-inflammatory properties. By reducing inflammation, Accutane addresses the redness and swelling associated with acne lesions, promoting clearer skin.
Anti-inflammatory Effects
- Accutane directly reduces inflammation in acne lesions. This leads to faster healing and reduced redness. The overall inflammatory response to acne is lessened.
This multi-pronged approach – reducing sebum, modifying skin cell behavior, and reducing inflammation – explains Accutane’s remarkable effectiveness in treating severe acne.
