Accutane, or isotretinoin, is a powerful medication often considered for severe, recalcitrant rosacea. However, it’s not a first-line treatment and carries significant risks.
Before starting Accutane for rosacea, discuss these key points with your dermatologist:
- Severity of your rosacea: Accutane is generally reserved for patients with severe inflammatory rosacea unresponsive to other therapies. Potential side effects: These can include dry skin, lips, and eyes; increased sun sensitivity; elevated cholesterol and triglycerides; and potential effects on liver function. Your doctor will monitor these closely. Pregnancy and breastfeeding: Accutane is teratogenic, meaning it can cause severe birth defects. Strict adherence to the iPledge program (in the US) is mandatory for women of childbearing age. Medication interactions: Accutane interacts with certain medications; inform your doctor about all medications and supplements you are taking. Alternative treatments: Explore other therapies, such as topical retinoids, azelaic acid, or antibiotics, before considering Accutane. These often provide excellent results without the risks associated with isotretinoin.
If your dermatologist approves Accutane for your rosacea, expect:
Initial low dose: Your doctor will likely start you on a low dose and gradually increase it. Regular monitoring: Blood tests and appointments are necessary to track side effects and adjust dosage. Gradual improvement: Rosacea symptoms might improve gradually over several weeks or months. Maintenance therapy: Once your symptoms improve, your dermatologist may recommend ongoing low-dose therapy, or a different medication to prevent relapse. Potential relapse: Rosacea can recur after completing Accutane; your doctor will work with you to develop a plan for managing potential future flare-ups.
Remember: Accutane is a powerful medication with potential side effects. A thorough discussion with your dermatologist is crucial to determine if the benefits outweigh the risks for your specific situation. Always follow your doctor’s instructions precisely.


